杨泱泱，博士，硕士生导师

Tel：021-64252419,；E-mail：triyang@ecust.edu.cn

实验十八楼1500室 

主要研究方向：
（1）特定核酸分子开关的设计与荧光标记，用于寡聚核酸链（DNA，mRNA，miRNA）检测与成像；
（2）制备高生物相容性、高靶向性纳米载药体，用于装载药物小分子或者生物大分子药物（如反义寡聚核苷酸，小分子干扰RNA）；
（3）以生物大分子如核酸，多肽为组装元件，制备可生物利用的凝胶材料，用于药物控制释放，组织修复与再生等应用研究
 

学术论文发表及专著出版：  

1. Yang, Y.; Cheng, T.; Zhu, W.; Xu, Y. *; Qian, X*. "Highly selective and sensitive near-infrared fluorescent sensors for cadmium in aqueous solution." Org. Lett. 2011, 13, 264-267.
2. Cheng, T.; Wang, T.; Zhu, W.; Yang, Y.; Zeng B.; Xu, Y. *; Qian, X*."Modulating the selectivity of near-IR fluorescent probes toward various metal ions by judicious choice of aqueous buffer solutions." Chem. Commun., 2011, 47, 3915-3917.
3. Endo, M.*; Yang, Y.; Emura, T.; Hidaka, K.; Sugiyama, H.*"Programmed placement of gold nanoparticles onto a slit-type DNA origami scaffold" Chem. Commun., 2011, 47, 10743-10745.
4. Yang, Y.; Endo, M.*; Hidaka, K.; Sugiyama, H.* "Photocontrollable DNA origami nanostructures assembling into predesigned multiorientational patterns" J. Am. Chem. Soc. 2012, 134, 20645-20653.
5. Endo, M.*; Yang, Y.; Suzuki, Y.; Hidaka, K.; Sugiyama, H*."Single-molecule visualization of the hybridization and dissociation of photoresponsiveoligonucleotides and their reversible switching behavior in a DNA nanostructure" Angew.Chem. Int. Ed. 2012, 51, 10518-10522.
6. Endo, M.*; Yang, Y.; Sugiyama, H.* "DNA origami technology for biomaterials applications" Biomater. Sci. 2013, 1, 347-360.
7. Suzuki, Y.; Endo, M.*; Yang, Y.; Sugiyama, H.* “Dynamic assembly/disassembly processes of photoresponsive DNA origami nanostructures directly visualized on a lipid membrane surface” J. Am. Chem. Soc. 2014, 136, 1714-1717.
8. Yang, Y.; Endo, M.*; Suzuki, Y.; Sugiyama, H.* “Direct observation of the dual-switching behaviors corresponding to the state transition in a DNA nanoframe” Chem. Comm. 2014, 50, 4211-4213.
9. Takenaka, T.; Endo, M.*; Suzuki, Y.; Yang, Y.; Emura, T.; Hidaka, K.; Kato, T.; Mitata, T.; Namba, K.; Sugiyama, H*. “Photoresponsive DNA nanocapsule having an open/close system for capture and release of nanomaterials” Chem. Eur. J. 2014, 14951-14954.
10. Yang Y, Goetzfried MA, Hidaka K, You M, Tan W, Sugiyama H, Endo M. Direct Visualization of Walking Motions of Photocontrolled Nanomachine on the DNA Nanostructure. Nano Lett. 2015, 15, 6672-6676.
11. Qiao Y, Chen B, Yang Y, Wang X, Xu Y, Li H. Rational design of a highly selective fluorescent sensor for L-histidine detection in aqueous solution. Dalton Trans. 2016, 45, 1310-1314.
12. Kuzyk A, Yang Y, Duan X, Stoll S, Govorov AO, Sugiyama H, Endo M, Liu N. A light-driven three-dimensional plasmonic nanosystem that translates molecular motion into reversible chiroptical function. Nat Commun. 2016, 10591.
13. Yang Y, Tashiro R, Suzuki Y, Emura T, Hidaka K, Sugiyama H, Endo M. “A Photoregulated DNA-Based Rotary System and Direct Observation of Its Rotational Movement.” Chem. Eur. J. 2017, 23, 3979-3985.